A specialized pathway affecting virulence glycoconjugates of Leishmania.

نویسندگان

  • A Descoteaux
  • Y Luo
  • S J Turco
  • S M Beverley
چکیده

For virulence and transmission, the protozoan parasite Leishmania must assemble a complex glycolipid on the cell surface, the lipophosphoglycan (LPG). Functional complementation identified the gene LPG2, which encodes an integral Golgi membrane protein implicated in intracellular compartmentalization of LPG biosynthesis. Ipg2- mutants lack only characteristic disaccharide-phosphate repeats, normally present on both LPG and other surface or secreted molecules considered critical for infectivity. In contrast, a related yeast gene, VAN2/VRG4, is essential and required for general Golgi function. These results suggest that LPG2 participates in a specialized virulence pathway, which may offer an attractive target for chemotherapy.

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عنوان ژورنال:
  • Science

دوره 269 5232  شماره 

صفحات  -

تاریخ انتشار 1995